Contribution to the Scientific Community. Hamari is a trend setter when it comes to developing new technology and applying its unique technology for commercial purposes. Contribution to the scientific community makes Hamari stands out from its competitors.
- Chemical dynamic kinetic resolution and S/R interconversion of unprotected α-amino acids. Angew. Chem. Int. Ed. 2014, 53, 12214–12217. DOI: 10.1002/anie.201407944
- Recyclable ligands for the non-enzymatic dynamic kinetic resolution of challenging α-amino acids. Angew. Chem. Int. Ed. 2015, 54, 12918–12922. DOI: 10.1002/anie.201507273
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Selected List of Published Research and Review Articles and Patents
The following is a selected list of peer-reviewed research articles authored by Hamari Chemicals, Ltd.
- Asymmetric Synthesis of 4,4‐(Difluoro)glutamic Acid via Chiral Ni(II)‐Complexes of Dehydroalanine Schiff Bases. Effect of the Chiral Ligands Structure on the Stereochemical Outcome. ChemistryOpen 2020, 9, 93-96. DOI: 10.1002/open.201900343
- Large-Scale Synthesis of the Glycine Schiff Base Ni(II) Complex Derived from (S)- and (R)-N-(2-Benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methyl]-2-pyrrolidinecarboxamide. Org. Process Res. Dev. 2020, 24, 294-300. DOI: 10.1021/acs.oprd.9b00399
- Development of Hamari Ligands for Practical Asymmetric Synthesis of Tailor-Made Amino Acids. ACS Omega 2019, 4, 18942-18947. DOI: 10.1021/acsomega.9b02940
- Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution. ACS Omega 2019, 4, 11844-11851. DOI: 10.1021/acsomega.9b01537
- Large‐Scale Asymmetric Synthesis of Fmoc‐(S)‐2‐Amino‐6,6,6‐Trifluorohexanoic Acid. ChemistryOpen 2019, 8, 701-704. DOI: 10.1002/open.201900131
- Optical Resolution of Rimantadine. Molecules 2019, 24, 1828. DOI: 10.3390/molecules24091828
- Convenient Asymmetric Synthesis of Fmoc-(S)-6,6,6-Trifluoro-Norleucine. Symmetry 2019, 11, 578. DOI: 10.3390/sym11040578
- Expedient Asymmetric Synthesis of (S)‑2-Amino-4,4,4-trifluorobutanoic Acid via Alkylation of Chiral Nucleophilic Glycine Equivalent. Org. Process Res. Dev. 2019, 23, 629–634. DOI: 10.1021/acs.oprd.8b00404
- Large Scale Synthesis of Chiral (3Z,5Z)‑2,7-Dihydro‑1H‑azepine-Derived Hamari Ligand for General Asymmetric Synthesis of Tailor-Made Amino Acids. Org. Process Res. Dev. 2019, 23, 619–628. DOI: 10.1021/acs.oprd.8b00406
The following is a selected review article authored by Hamari Chemicals, Ltd.
- Cyclic tailor-made amino acids in the design of modern pharmaceuticals. Eur. J. Med. Chem. 2020, 208, 112736. DOI: 10.1016/j.ejmech.2020.112736
- Tailor-made amino acids and fluorinated motifs as prominent traits in modern pharmaceuticals. Chem. Eur. J. 2020, 26, 11349-11390. [Reviews Showcase] DOI: 10.1002/chem.202085061
- Applications of fluorine-containing amino acids for drug design. Eur. J. Med. Chem. 2020, 186, 111826. DOI: 10.1016/j.ejmech.2019.111826
- The second-generation of highly potent Hepatitis C virus (HCV) NS3/4A protease inhibitors: Evolutionary design based on tailor-made amino acids, synthesis and major features of bio-activity. Curr. Pharm. Des. 2017, 23, 4493–4554. DOI: 10.2174/1381612823666170522122424
- New routes to tailor-made amino acids. Speciality Chemicals Magazine March 2016, 36, 42–43. Corpus ID: 90106437
- Next generation of fluorine-containing pharmaceuticals, compounds currently in Phase II–III clinical trials of major pharmaceutical companies: New structural trends and therapeutic areas. Chem. Rev. 2016, 116, 422–518. DOI: 10.1021/acs.chemrev.5b00392
- Small-molecule therapeutics for Ebola virus (EBOV) disease treatment. Eur. J. Org. Chem. 2016, 1, 8–16. DOI: 10.1002/ejoc.201501158
- Tailor-made α-amino acids in the pharmaceutical industry: Synthetic approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic acid (Vinyl-ACCA). Eur. J. Org. Chem. 2016, 16, 2757–2774. DOI: 10.1002/ejoc.201600112
- Recent advances in the trifluoromethylation methodology and new CF3-containing drugs. J. Fluorine Chem. 2014, 167, 37–54. DOI: 10.1016/j.jfluchem.2014.06.026
- Synthesis of fluorine-containing α-amino acids in enantiomerically pure form via homologation of Ni(II) complexes of glycine and alanine Schiff bases. J. Fluorine Chem. 2013, 155, 21–38. DOI: 10.1016/j.jfluchem.2013.06.004
The following is a selected list of patents by Hamari Chemicals, Ltd.
- METHOD FOR SYNTHESIZING OPTICALLY ACTIVE α-AMINO ACID USING CHIRAL METAL COMPLEX COMPRISING AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL]ACETAMIDE COMPOUND AND AMINO ACID. WO2014188783.
- AXIAL-ASYMMETRIC N-(2-ACYLARYL)-2-[5, 7-DIHYDRO-6H-DIBENZO [C, E] AZEPINE-6-YL] ACETAMIDE COMPOUND AND CHIRALITY CONVERSION METHOD FOR [Alpha]-AMINO ACID USING SAME. WO2014098063.
- METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOL. WO2013061999.
- METHOD FOR PRODUCING OPTICALLY ACTIVE TETRAHYDROQUINOLINE. WO2013011930.
- METHOD FOR PRODUCING FINE POWDER OF LOXOPROFEN SODIUM DIHYDRATE FOR PHARMACEUTICAL PREPARATIONS. WO2012137667.
- NOVEL DIHYDROTRIAZINE DERIVATIVE. WO2010024225.
- PROCESS FOR PRODUCTION OF ETHYNYLTHYMIDINE COMPOUND USING 5-METHYLURIDINE AS STARTING RAW MATERIAL. WO2009125841.
- METHOD FOR PURIFYING ETHYNYLTHYMIDINE COMPOUND. WO2009119785.
- METHOD FOR SYNTHESIZING L-ANSERINE. JP2005082571.
- NOVEL 2,4-DIAMINO-1,3,5-TRIAZINE DERIVATIVE. WO2004054989.