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Zinc and COVID-19

“Zinc and respiratory tract infections: Perspective for COVID-19 (Review)” is an international collaborative review from Germany, Greece, Norway, Russia and USA academies, centers, colleges, hospitals, institutes and universities (Int. J. Mol. Med., 46: 17-26, 2020). In this in-depth review, the authors suggested that modulation of zinc status may be beneficial in COVID-19. The SARS-CoV-2 virus is the cause of the COVID-19 pandemic leading to lung diseases, namely pneumonia, ARDS (very severe pneumonia) and ventilator-induced injuries.

  1. Zinc works on the mucus lung cells by activating the removal of the virus and also inducing barrier activation, and therefore, the virus is prevented from penetrating deeper inside the body.
  2. Zinc may prevent viral replication before the viral uncoding and before the viral transcription stages.
  3. Zinc may boost antiviral activities by upregulating IFNα.
  4. COVID-19 induces inflammation that aggravates the disease state. Zinc limits excessive inflammatory responses thereby preventing the devastative cytokine storm.
  5. Bacterial co-infection from viral pneumonia is a commonly high risk. Zinc induces inhibition of Streptococcus pneumonia growth via modulation of bacterial Mn(II) homeostasis.
  6. High COVID-19 mortality and zinc deficiency share the same risk factors: ageing, immune deficiency and metabolic diseases (obesity, diabetes, atherosclerosis, etc.). The authors concluded that zinc supplementation may have beneficial effects in modulating at least some of the risk factors for high COVID-19 mortality.

Hamari Chemicals, Ltd. is the inventor and manufacturer of a zinc supplement, PepZinGI.

Disclaimer: The text and illustration were composed under fair use law as a summary of a scientific review titled, “Zinc and respiratory tract infections: Perspective for COVID-19 (Review)” published in Int. J. Mol. Med., 46: 17-26, 2020.

    2021/4/1


Moving to New Location

We, Hamari Chemicals USA, have relocated our laboratory within the greater Sorrento Valley area. We look forward to continuing to serve you in all of your custom synthesis needs.

 
New Address
11558 Sorrento Valley Road, Suite 3
San Diego, California, 92121, USA
Tel.+1-858-704-4395
Fax.+1-858-704-4398
 

    2020/10/15


Developing a Cost-effective Procedure for Porphyrins

We recently developed a cost-effective procedure to synthesize 5,10,15,20-tetrakis(pentfluorophenyl)porphrin (CAS#25440-14-6) and Platinum 5,10,15,20-tetrakis(pentfluorophenyl)porphyrin (CAS#109781-47-7) based on customer requirement.

 

We successfully reduced the cost of these compounds by more than 50% compared to market price.  Our synthetic procedure for four-substituted porphyrin and Pt-insertion has significant advantages over those described in the literature.

 

 

 

✓High Quality (≧98% HPLC purity)

✓High Yield (more than the yield described in the literature)

✓Cost-effective (eliminate column purification)

 

Custom synthesis of porphyrin derivatives as well as any organic compound based on your structural requirements is available from Hamari Chemicals USA, Inc.

Please call or e-mail us to receive pricing and quotes.

Tel: +1-858-704-4395

E-mail: [email protected]

    2020/2/28


A Large-Scale Synthesis of Ni(II) complex Published in Org. Process Res. Dev.

This is a recently published paper of our core technology.

 

 

Large-Scale Synthesis of the Glycine Schiff Base Ni(II) Complex Derived from (S)– and (R)-N-(2-Benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methly]-2-pyrrolidinecarboxamide]

Org. Process Res. Dev. , 2020, ASAP

 

 

 

Custom synthesis of amino acids, tailor-made to your structural requirements, D or L, is available from Hamari Chemicals USA, Inc.

Please call or e-mail us to get pricing and quotes.

Tel: +1-858-704-4395

E-mail: [email protected]

    2020/1/29


A Review on Hamari Ligands Published in ACS Omega

This is a recently published review of our core technology and its applications.

 

Development of Hamari Ligands for Practical Asymmetric Synthesis of Tailor-Made Amino Acids. ACS Omega, 2019, 4, 18942-18947

 

Custom synthesis of amino acids, tailor-made to your structural requirements, D or L, is available from Hamari Chemicals USA, Inc.

Please call or e-mail us to get pricing and quotes.

Tel: +1-858-704-4395

E-mail: [email protected]

    2019/12/6


High Quality Fmoc-L-alloisoleucine

We recently successfully synthesized Fmoc-L-alloisoleucine at high chemical and optical purity.

 

 

Custom synthesis of amino acids, tailor-made to your structural requirements, D or L, is available from Hamari Chemicals USA, Inc.

 

Please call or e-mail us to get pricing and quotes.

Tel: +1-858-704-4395

E-mail: [email protected]

    2019/11/22